Yttrium-90

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Yttrium-90
General
Name, symbol Yttrium-90,90Y
Neutrons 51
Protons 39
Nuclide data
Half-life 64.1 h
Complete table of nuclides

Yttrium-90, 90
Y
, is a medically significant isotope of yttrium.[1] Yttrium-90 has a wide and valuable use in radiation therapy to treat cancer.[2]

Decay

90
Y
undergoes β decay to zirconium-90 with a half-life of 64.1 hours[3] and a decay energy of 2.28 MeV.[4] It also produces 0.01% 1.7 MeV[5] photons along the way. Interaction of the emitted electrons with matter can lead to Bremsstrahlung radiation.

Production

Yttrium-90 is a decay product of strontium-90 which makes up about 5% of the nuclear daughter isotopes when uranium is fissioned.[6][not in citation given] Yttrium-90 is produced by chemical high-purity separation from strontium-90, a fission product of uranium in nuclear reactors.[7]

Clinical Application

90Y plays a significant role in the treatment of hepatocellular carcinoma (HCC) and other liver cancers. Trans-arterial radioembolization is a procedure performed by interventional radiologists in which microspheres are impregnated with 90Y and injected into the arteries supplying the tumor.[8] Radioembolization with 90Y significantly increases time-to-progression (TTP) of HCC,[9] has a tolerable adverse event profile, and improves patient quality of life more than do similar therapies.[10]

See also

References

  1. ^ Vincent T. DeVita; Theodore S. Lawrence; Steven A. Rosenberg; Robert A. Weinberg; Ronald A. DePinho (1 April 2008). DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology. Lippincott Williams & Wilkins. pp. 2507–. ISBN 978-0-7817-7207-5. Retrieved 9 June 2011. 
  2. ^ Arkadiy Kheyfits (October 2010). "Yttrium-90 Radioembolization". Radiology Today. Retrieved 2012-10-23. 
  3. ^ "Y-90 Handling Precautions" (PDF). Retrieved 2015-07-15. 
  4. ^ "Table of Isotopes decay data". The Lund/LBNL Nuclear Data Search. February 1999. Retrieved 2012-10-23. 
  5. ^ Rault, E.; Vandenberghe, S.; Staelens, S.; Lemahieu, I. (2009). Optimization of Yttrium-90 Bremsstrahlung Imaging with Monte Carlo Simulations. 4th European Conference of the International Federation for Medical and Biological Engineering. 22. pp. 500–504. Retrieved 21 October 2013. 
  6. ^ "Strontium | Radiation Protection | US EPA". EPA. 24 April 2012. Retrieved 2012-10-23. 
  7. ^ "PNNL: Isotope Sciences Program - Yttrium-90 Production". PNNL. February 2012. Retrieved 2012-10-23. 
  8. ^ Kallini JR, Gabr A, Salem R, Lewandowski RJ. (2 April 2016). "Trans-arterial Radioembolization with Yttrium-90 for the Treatment of Hepatocellular Carcinoma". Adv Ther. 
  9. ^ Salem R, Gordon AC, Mouli S, Hickey R, Kallini J; et al. (Aug 26, 2016). "Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma". Gastroenterology. 151: 1155–1163.e2. doi:10.1053/j.gastro.2016.08.029. PMC 5124387Freely accessible. PMID 27575820. 
  10. ^ Salem, R. Gilbertsen, M. Butt, Z. Memon, K. Vouche, M. Hickey, R. Baker, T. Abecassis, M. M. Atassi, R. Riaz, A. Cella, D. Burns, J. L. Ganger, D. Benson, A. B., 3rd Mulcahy, M. F. Kulik, L. Lewandowski, R. (2013). "Increased quality of life among hepatocellular carcinoma patients treated with radioembolization, compared with chemoembolization". Clin Gastroenterol Hepatol. 11 (10): 1358–1365.e1. doi:10.1016/j.cgh.2013.04.028. 

11. E. V. Marathe (July 1955). "The Half-Life of Yttrium-90". Journal of Scientific & Industrial Research (Vol 14B ed.). The Council of Scientific & Industrial Research, New Delhi: 354–355.

External links

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