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U-92016A structure.png
CAS Number
  • 149654-41-1 ☑Y
PubChem CID
  • 9904242
  • 30
  • 8079896 ☑Y
  • ChEMBL71920 ☑Y
CompTox Dashboard (EPA)
  • DTXSID00432645
Chemical and physical data
Formula C19H25N3
Molar mass 295.421 g/mol g·mol−1
3D model (JSmol)
  • Interactive image

U-92,016-A is a psychoactive drug and research chemical used in scientific studies. It acts as a potent, high efficacy, and selective 5-HT1A receptor full agonist with a long duration of action.[1][2] It has been suggested that it could be developed as an anxiolytic or antidepressant drug.[1]


  1. ^ a b Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F (1993). "Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants". J Med Chem. 36 (15): 2066–2074. doi:10.1021/jm00067a003. PMID 8101876.
  2. ^ McCall RB, Romero AG, Bienkowski MJ, Harris DW, McGuire JC, Piercey MF, Shuck ME, Smith MW, Svensson KA, Schreur PJ, et al. (1994). "Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist". J Pharmacol Exp Ther. 271 (2): 875–883. PMID 7965808.

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