Troleandomycin

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Troleandomycin
Troleandomycin.png
Clinical data
AHFS/Drugs.com Multum Consumer Information
MedlinePlus a604026
ATC code
Identifiers
CAS Number
  • 2751-09-9 ☑Y
PubChem CID
  • 5284630
DrugBank
  • DB01361 ☑Y
ChemSpider
  • 4447675 ☑Y
UNII
  • C4DZ64560D
KEGG
  • D01322 ☒N
ChEBI
  • CHEBI:45735 ☒N
ChEMBL
  • CHEMBL564085 ☒N
PDB ligand
  • TAO (PDBe, RCSB PDB)
ECHA InfoCard 100.018.539
Chemical and physical data
Formula C41H67NO15
Molar mass 813.968 g/mol
3D model (JSmol)
  • Interactive image
 ☒N☑Y (what is this?)   (verify)

Troleandomycin (TAO for short[1]) is a macrolide antibiotic. It was sold in Italy (branded Triocetin) and Turkey (branded Tekmisin). It is no longer sold in Italy as of 2018.[citation needed]

The drug's mode of action is to bind to the ribosome, specifically in the tunnel through which the newly formed peptide egresses, thereby halting protein synthesis[2]. Troleandomycin is a CYP3A4 inhibitor that may cause drug interactions.

References

  1. ^ Zeiger, Robert S.; Schatz, Michael; Sperling, William; Simon, Ronald A.; Stevenson, Donald D. (1980). "Efficacy of troleandomycin in outpatients with severe, corticosteroid-dependent asthma". Journal of Allergy and Clinical Immunology. 66 (6): 438–446. doi:10.1016/0091-6749(80)90003-2. ISSN 0091-6749.
  2. ^ Blaha, G.; Steitz,, T. A.; Moore, P. B.; Gurel, G. (2009). "Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortui". Antimicrobial Agents and Chemotherapy. 53 (12): 5010–5014. doi:10.1128/AAC.00817-09. ISSN 0066-4804. PMC 2786347. PMID 19738021.


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