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Chemical structure of tetrazolylglycine
IUPAC name
(RS)-Amino(1H-tetrazol-5-yl)acetic acid
  • 138199-51-6 ☒N
3D model (JSmol)
  • Interactive image
  • ChEMBL140784 ☑Y
  • 112321 ☑Y
  • 4068
PubChem CID
  • 126383
Molar mass 143.106 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is ☑Y☒N ?)
Infobox references

Tetrazolylglycine (Tet-Gly, LY-285,265) is a potent and selective NMDA receptor agonist, stimulating the NMDA receptor with higher potency than either glutamate or NMDA.[1] It is a potent convulsant and excitotoxin and is used in scientific research.[2][3]


  1. ^ Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ (1992). "DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy". Journal of Medicinal Chemistry. 35 (24): 4608–12. doi:10.1021/jm00102a015. PMID 1361579.
  2. ^ Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH (1991). "D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist". European Journal of Pharmacology. 203 (2): 237–43. doi:10.1016/0014-2999(91)90719-7. PMID 1686860.
  3. ^ Schoepp DD, Lunn WH, Salhoff CR, McDonald JW (1994). "The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin". European Journal of Pharmacology. 270 (1): 67–72. doi:10.1016/0926-6917(94)90081-7. PMID 8157082.
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