Talk:Selenium deficiency

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WikiProject Medicine / Dermatology  (Rated Start-class, Mid-importance)
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Please someone add this section below on selenium and cancer to the article

Cancer cell line studies have shown that selenium yeast has beneficial effects on oxidative stress, tumor growth inhibition, and apoptosis in human breast cancer cells [Guo - see reference below]. Cancer cell line studies have also shown that supplemental selenium and the anti-cancer chemotherapy drug cisplatin, combined, can result in a significant anti-breast cancer effect [Sakalli Çetin - see below]. Animal studies have consistently shown that selenium supplementation helps to suppress the formation of breast cancer cells [Ekoue]. Most human epidemiological studies (reports of observational studies) have shown an inverse association between selenium status and intakes and the risk of breast cancer [Ekoue]. Dr. Cai and a team of researchers have done a meta-analysis of 69 observational studies of selenium exposure and cancer risk. 14 of the studies had breast cancer as an outcome. The data from the 14 studies show that higher selenium exposure was significantly associated with decreased risk of breast cancer [Cai].

References: Cai, X., Wang, C., Yu, W., Fan, W., Wang, S., Shen, N., & Wang, F. (2016). Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. Scientific Reports, 619213. doi:10.1038/srep19213

Ekoue, D. N., Zaichick, S., Valyi-Nagy, K., Picklo, M., Lacher, C., Hoskins, K., & Diamond, A. M. (2017). Selenium levels in human breast carcinoma tissue are associated with a common polymorphism in the gene for SELENOP (Selenoprotein P). Journal of Trace Elements in Medicine and Biology, 39,227-233.

Guo, C., Hsia, S., Shih, M., Hsieh, F., & Chen, P. (2015). Effects of Selenium Yeast on Oxidative Stress, Growth Inhibition, and Apoptosis in Human Breast Cancer Cells. International Journal of Medical Sciences, 12(9), 748-758.

Méplan, C., Dragsted, L. O., Ravn-Haren, G., Tjønneland, A., Vogel, U., & Hesketh, J. (2013). Association between polymorphisms in glutathione peroxidase and selenoprotein P genes, glutathione peroxidase activity, HRT use and breast cancer risk. Plos One, 8(9), e73316. doi:10.1371/journal.pone.0073316

Sakalli Çetin, E., Nazıroğlu, M., Çiğ, B., Övey, İ. S., & Aslan Koşar, P. (2017). Selenium potentiates the anticancer effect of cisplatin against oxidative stress and calcium ion signaling-induced intracellular toxicity in MCF-7 breast cancer cells: involvement of the TRPV1 channel. Journal of Receptor And Signal Transduction Research, 37(1), 84-93.

Article categorization

This article was initially categorized based on scheme outlined at WP:DERM:CAT. kilbad (talk) 23:36, 20 February 2009 (UTC)

few cases have been reported

Which doctor is carrying out checks? No check = no report. — Preceding unsigned comment added by (talk) 04:24, 14 November 2011 (UTC)

I concur with the above. I had multiple and obvious symptoms but only ended up discovering the test as part of a blood profile i personally ordered and paid for. Some doctors who do test for it report it is common in certain groups of patients. — Preceding unsigned comment added by Leopardtail (talkcontribs) 17:02, 24 May 2014 (UTC)

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