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comparative efficacy and tolerability table

this is a gobsmacking work of WP:OR; the refs are horribly out of date as well.

Comparative efficacy and tolerability


  1. ^ a b c d e f g h i j k l Cite error: The named reference SJW Cochrane review was invoked but never defined (see the help page).
  2. ^ a b c d e f g Brunton LL, Chabner B, Knollmann BC, eds. (2011). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-162442-8.
  3. ^ a b c d e f g h i j k "Side effects of antidepressant medications". UpToDate. Wolters Kluwer Health. Archived from the original on 2 November 2013. Retrieved 24 October 2013.
  4. ^ a b c d e f g h i j k l m n o Royal Pharmaceutical Society of Great Britain. MARTINDALE – The Complete Drug Reference. Pharmaceutical Press. Archived from the original on 26 July 2013. Retrieved 31 October 2013.
  5. ^ a b c d e f g h i j k l Ernst E; Rand JI; Barnes J; Stevinson C (1998). "Adverse effects profile of the herbal antidepressant St. John's wort (Hypericum perforatum L.)". European Journal of Clinical Pharmacology. 54 (8): 589–94. doi:10.1007/s002280050519. PMID 9860144. Collectively, the data suggest that hypericum is well tolerated, with an incidence of adverse reactions similar to that of placebo.
  6. ^ a b c Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, Watanabe N, Nakagawa A, Omori IM, McGuire H, Tansella M, Barbui C (2009). "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis". Lancet. 373 (9665): 746–58. doi:10.1016/S0140-6736(09)60046-5. PMID 19185342.
  7. ^ a b c d e f g h i j k l Taylor D, Paton C, Shitij K (2012). The Maudsley prescribing guidelines in psychiatry. West Sussex: Wiley-Blackwell. ISBN 978-0-470-97948-8.
  8. ^ a b White N, Litovitz T, Clancy C (2008). "Suicidal antidepressant overdoses: a comparative analysis by antidepressant type". J Med Toxicol. 4 (4): 238–50. doi:10.1007/BF03161207. PMC 3550116. PMID 19031375.
  9. ^ a b c d e f g h Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
  10. ^ a b van Moffaert M, de Wilde J, Vereecken A, Dierick M, Evrard JL, Wilmotte J, Mendlewicz J (March 1995). "Mirtazapine is more effective than trazodone: a double-blind controlled study in hospitalized patients with major depression". Int Clin Psychopharmacol. 10 (1): 3–9. doi:10.1097/00004850-199503000-00001. PMID 7622801.
  11. ^ a b c d e f g h i j k Voican, CS; Corruble, E; Naveau, S; Perlemuter, G (April 2014). "Antidepressant-induced liver injury: a review for clinicians". The American Journal of Psychiatry. 171 (4): 404–15. doi:10.1176/appi.ajp.2013.13050709. PMID 24362450.
  12. ^ "AMOXAPINE tablet [Watson Laboratories, Inc.]". DailyMed. Watson Laboratories, Inc. August 2010. Archived from the original on 2 November 2013. Retrieved 30 October 2013.
  13. ^ a b Walker, R, Whittlesea, C, eds. (2007) [1994]. Clinical Pharmacy and Therapeutics (4th ed.). Edinburgh: Churchill Livingstone Elsevier. ISBN 978-0-7020-4293-5.
  14. ^ Bruijn JA, Moleman P, Mulder PG, van den Broek WW, van Hulst AM, van der Mast RC, van de Wetering BJ (1996). "A double-blind, fixed blood-level study comparing mirtazapine with imipramine in depressed in-patients" (PDF). Psychopharmacology. 127 (3): 231–7. doi:10.1007/BF02246131. PMID 8912401. Archived (PDF) from the original on 18 August 2017.
  15. ^ Bruijn JA, Moleman P, Mulder PG, van den Broek WW (1999). "Depressed in-patients respond differently to imipramine and mirtazapine". Pharmacopsychiatry. 32 (3): 87–92. doi:10.1055/s-2007-979200. PMID 10463374.
  16. ^ a b Fishback JA, Robson MJ, Xu YT, Matsumoto RR (2010). "Sigma receptors: potential targets for a new class of antidepressant drug". Pharmacol. Ther. 127 (3): 271–82. doi:10.1016/j.pharmthera.2010.04.003. PMC 3993947. PMID 20438757.
  17. ^ a b Kishimoto A, Todani A, Miura J, Kitagaki T, Hashimoto K (2010). "The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report". Ann Gen Psychiatry. 9: 23. doi:10.1186/1744-859X-9-23. PMC 2881105. PMID 20492642.
  18. ^ Borkowska A, Pilaczyńska E, Araszkiewicz A, Rybakowski J (2002). "[The effect of sertraline on cognitive functions in patients with obsessive-compulsive disorder]". Psychiatr. Pol. (in Polish). 36 (6 Suppl): 289–95. PMID 12647451.
  19. ^ Schmitt JA, Ramaekers JG, Kruizinga MJ, van Boxtel MP, Vuurman EF, Riedel WJ (2002). "Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man". J. Psychopharmacol. 16 (3): 207–14. doi:10.1177/026988110201600303. PMID 12236626.
  20. ^ Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8.
  21. ^ Goodwin GM (2009). "Clinical studies on the efficacy of agomelatine on depressive symptoms". CNS Drugs. 23 Suppl 2: 35–9. doi:10.2165/11318650-000000000-00000. PMID 19708724.

-- Jytdog (talk) 20:50, 23 January 2018 (UTC)


Help me understand how these uniform rankings culled from all these sources is not a completely inappropriate work of WP:OR. Jytdog (talk) 21:02, 23 January 2018 (UTC)

I would really like someone who knows a thing or two about antidepressants to step in here. To me, the table contains useful and important information that you don't get anywhere else in the article. I know that Jytdog deleted the subpage "Comparative efficacy and tolerability of antidepressants" created by Doc James and I do not agree with his reasoning. (talk) 23:43, 10 February 2018 (UTC)
Well, the userpage of the (still active) editor that made this in 2013 is fully supportive of using reliable sourcing...should we get his input or not?Petergstrom (talk) 00:06, 11 February 2018 (UTC)
I say go ahead and get Fuse809's input. (talk) 03:02, 12 February 2018 (UTC)
It was a summary of the sources. Thought it was a good deed, but if you's dislike it and think of it as inappropriate feel free to delete it. I think this deletion would reduce the quality of this article, but alas I may be bias as it was the product of my several hours of work. Fuse809 (contribs · email · talk · uploads) 07:17, 12 February 2018 (UTC)
Fits best as a separate article as articles should not generally have hidden text. I have no strong feels one way or the other. Doc James (talk · contribs · email) 08:20, 12 February 2018 (UTC)

Redirect link

The subpage link for comparative efficacy and tolerability leads straight back to the main page on antidepressants, can someone please fix this as I need that chart — Preceding unsigned comment added by (talk) 09:33, 4 February 2018 (UTC)

Prior content is here[1] Doc James (talk · contribs · email) 23:57, 10 February 2018 (UTC)
Are you going to fight to get that subpage reinstated, Doc James? (talk) 03:02, 12 February 2018 (UTC)
Not planning too right now. If there is consensus to keep it happy to restore. Doc James (talk · contribs · email) 08:34, 12 February 2018 (UTC)

Adding a section on antidepressant adherence

I plan on adding a sub-section on antidepressant adherence to the article. I will be adding this sub-section under the "society and culture" section of the article after sub-section 7.2 "most commonly prescribed." Anthonyb9798 (talk) 17:34, 1 March 2018 (UTC)

Antidepressant withdrawal symptoms

This seems relevant for the section on discontinuation syndrome:

A new systematic review reports that about half of the patients discontinuing anti-depressants experience withdrawal symptoms. About half of those who experiencing withdrawal symptoms consider them severe.

<redact likely WP:COPYLINK violation>

While most data is on SSRI/SNRI, the review also includes some studies on tricyclics and MAOIs. Another question that this review raises is whether 'discontinuation syndrome' should actually be replaced by 'withdrawal'. The article argues in favour of the latter on the basis of incidence, severity and duration of the withdrawal effects.Lucleon (talk) 20:03, 2 October 2018 (UTC)

I've removed what appears to be a WP:COPYLINK violation. See also here - the paper has been temporarily retracted for some reason. (prior link is archiveurl for today; here is the live sciencedirect link, which may change) Jytdog (talk) 20:12, 2 October 2018 (UTC)
Thanks for the immediate feedback. Interesting... well then let's wait until this is clarified. The PDF of the paper is still linked at the end of the press release from appg on (link above). Lucleon (talk) 20:21, 2 October 2018 (UTC)

The paper is online now: including the following main claims:

"-More than half (56%) of people who attempt to come off antidepressants experience withdrawal effects.

-Nearly half (46%) of people experiencing withdrawal effects describe them as severe.

-It is not uncommon for the withdrawal effects to last for several weeks or months. ". I'd be happy to draft a short summary if this considered sufficient support for including it in the section discontinuation syndrome here and probably as well in the respective section for SSRI. Lucleon (talk) 12:49, 3 October 2018 (UTC)

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