TREX2

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TREX2
Protein TREX2 PDB 1y97.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TREX2, three prime repair exonuclease 2
External IDs MGI: 1346343 HomoloGene: 8046 GeneCards: TREX2
Gene location (Human)
X chromosome (human)
Chr. X chromosome (human)[1]
X chromosome (human)
Genomic location for TREX2
Genomic location for TREX2
Band Xq28 Start 153,444,720 bp[1]
End 153,470,587 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080701
NM_080699
NM_080700

NM_011907

RefSeq (protein)

NP_542432

NP_036037

Location (UCSC) Chr X: 153.44 – 153.47 Mb Chr X: 73.43 – 73.44 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Three prime repair exonuclease 2 is an enzyme that in humans is encoded by the TREX2 gene.[5][6]

This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183479 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031372 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Mazur DJ, Perrino FW (Aug 1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases". J Biol Chem. 274 (28): 19655–60. doi:10.1074/jbc.274.28.19655. PMID 10391904.
  6. ^ a b "Entrez Gene: TREX2 three prime repair exonuclease 2".

Further reading



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