RH-34

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
RH-34
RH-34 structure.png
Clinical data
Routes of
administration
?
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
  • 1028307-48-3 No
PubChem CID
  • 10041987
ChemSpider
  • 8217551 No
UNII
  • A31AED225O
Chemical and physical data
Formula C18H19N3O3
Molar mass 325.361 g/mol
3D model (JSmol)
  • Interactive image
 NoYesY (what is this?)  (verify)

RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.[1][2][3]

Legal status

RH-34 is a controlled substance in Hungary.[4]

See also

References

  1. ^ Ralf Heim. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)
  2. ^ Maria Silva. Theoretical study of the interaction of agonists with the 5-HT2A receptor. Universität Regensburg, 2009.
  3. ^ Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). "Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor". Journal of Computer-aided Molecular Design. 25 (1): 51–66. doi:10.1007/s10822-010-9400-2. PMID 21088982. 
  4. ^ A Magyarországon megjelent, a Kábítószer és Kábítószer-függőség Európai Megfigyelő Központjának Korai Jelzőrendszerébe (EMCDDA EWS) 2005 óta bejelentett ellenőrzött anyagok büntetőjogi vonatkozású besorolása
Retrieved from "https://en.wikipedia.org/w/index.php?title=RH-34&oldid=762265030"
This content was retrieved from Wikipedia : http://en.wikipedia.org/wiki/RH-34
This page is based on the copyrighted Wikipedia article "RH-34"; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License (CC-BY-SA). You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA