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Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
CAS Number
PubChem CID
  • 164739
  • 508
  • DB06707 ☑Y
  • 144416 ☑Y
  • V008L6478D
  • D02388 ☑Y
  • ChEMBL677 ☑Y
ECHA InfoCard 100.113.606
Chemical and physical data
Formula C9H13NO3
Molar mass 183.204 g/mol
3D model (JSmol)
  • Interactive image
 ‹See TfM›☒N☑Y (what is this?)   (verify)

Corbadrine (INN; marketed as Neo-Cobefrine), also known as levonordefrin (USAN) and α-methylnorepinephrine, is a catecholamine sympathomimetic used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States,[1][2] (usually in a pre-mixed solution with local anesthetics, such as mepivacaine).[3]

Corbadrine is also a metabolite of the antihypertensive drug methyldopa,[4] and plays a role in its pharmacology and effects.

See also


  1. ^ Dr. Ian Morton; I.K. Morton; Judith M. Hall (31 October 1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 164–. ISBN 978-0-7514-0499-9.
  2. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 275–. ISBN 978-3-88763-075-1.
  3. ^ "DailyMed — Search results for levonordefrin". DailyMed. Retrieved 20 February 2016.
  4. ^ Sjoerdsma, A; Vendsalu, A; Engelman, K; Watts, D (1 October 1963). "Studies on the Metabolism and Mechanism of Action of Methyldopa". Circulation. 28 (4): 492–502. doi:10.1161/01.CIR.28.4.492.

External links

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