NEFM

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NEFM
Identifiers
Aliases NEFM, NEF3, NF-M, NFM, neurofilament, medium polypeptide, neurofilament medium
External IDs HomoloGene: 38041 GeneCards: NEFM
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for NEFM
Genomic location for NEFM
Band 8p21.2 Start 24,913,012 bp[1]
End 24,919,098 bp[1]
RNA expression pattern
PBB GE NEFM 205113 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005382
NM_001105541

n/a

RefSeq (protein)

NP_001099011
NP_005373

n/a

Location (UCSC) Chr 8: 24.91 – 24.92 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.[3][4]

Function

Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.[4]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104722 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Ding Y, Reed DR, Baltazar MC, Price RA (May 1992). "RFLP for BgI II at the human neurofilament medium chain (NEF3) gene locus". Nucleic Acids Res. 20 (6): 1429. doi:10.1093/nar/20.6.1429-a. PMC 312205. PMID 1348579.
  4. ^ a b "Entrez Gene: NEFM neurofilament, medium polypeptide 150kDa".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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