NBQX

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
NBQX
NBQX.svg
Space-filling model of the NBQX molecule
Names
IUPAC name
6-Nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
Identifiers
  • 118876-58-7 ☑Y
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL222519 ☑Y
ChemSpider
  • 2521927 ☑Y
ECHA InfoCard 100.149.984
  • 4264
KEGG
  • C13667 ☑Y
PubChem CID
  • 3272524
Properties
C12H8N4O6S
Molar mass 336.281
Appearance brown/red powder
Soluble to 100 mM in DMSO
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☑Y verify (what is ☑Y☒N ?)
Infobox references

NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline) is an AMPA receptor antagonist.

NBQX blocks AMPA receptors in micromolar concentrations (~10–20 µM) and also blocks kainate receptors. In experiments, it is used to counter glutamate excitotoxicity.[1] NBQX was found to have anticonvulsant activity in rodent seizure models.[2]

As the disodium salt, NBQX is soluble in water at high concentrations (at least up to 100 mM).[3]

See also

References

  1. ^ Pitt, D.; Werner, P.; Raine, C. S. (2000). "Glutamate excitotoxicity in a model of multiple sclerosis". Nat Med. 6 (1): 67–70.
  2. ^ Yamaguchi, S.; Donevan, S.D.; Rogawski, M.A. (1993). Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. Epilepsy Res. 15:179–184.
  3. ^ Vendor product information



Retrieved from "https://en.wikipedia.org/w/index.php?title=NBQX&oldid=865069941"
This content was retrieved from Wikipedia : http://en.wikipedia.org/wiki/NBQX
This page is based on the copyrighted Wikipedia article "NBQX"; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License (CC-BY-SA). You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA