NAN-190

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NAN-190
Skeletal formula of NAN-190
Space-filling model of the NAN-190 molecule
Identifiers
CAS Number
  • 115388-32-4 ☑Y
PubChem CID
  • 4431
IUPHAR/BPS
  • 73
ChemSpider
  • 4278 ☒N
ChEMBL
  • CHEMBL8618 ☒N
Chemical and physical data
Formula C23H27N3O3
Molar mass 393.478 g/mol
3D model (JSmol)
  • Interactive image
 ☒N☑Y (what is this?)  (verify)

NAN-190 is a drug and research chemical widely used in scientific studies. It was previously believed to act as a selective 5-HT1A receptor antagonist, but a subsequent discovery showed that it also potently blocks the α2-adrenergic receptor.[1] The new finding has raised significant concerns about studies using NAN-190 as a specific serotonin receptor antagonist.[1]

References

  1. ^ a b Foong JP, Bornstein JC (2009). "5-HT antagonists NAN-190 and SB 269970 block alpha2-adrenoceptors in the guinea pig". NeuroReport. 20 (3): 325–330. doi:10.1097/WNR.0b013e3283232caa. PMID 19190523. 


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