Methylscopolamine bromide

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Methylscopolamine bromide
Clinical data
Trade names Pamine, Extendryl, AlleRx, Rescon
AHFS/ Monograph
MedlinePlus a606008
ATC code
Pharmacokinetic data
Elimination half-life 3–4 hrs
CAS Number
  • 155-41-9
PubChem CID
  • 441342
  • DB00462 ☑Y
  • 21106347 ☑Y
  • RTN51LK7WL
  • CHEMBL376897 ☑Y
ECHA InfoCard 100.005.314
Chemical and physical data
Formula C18H24NO4
Molar mass 318.388 g/mol (398.297 g/mol with bromide)
3D model (JSmol)
  • Interactive image

Methylscopolamine or methscopolamine, usually provided as the bromide salt (trade name Pamine) but sometimes as the nitrate salt Hyoscine methonitrate, is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion.[1] Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications[2] (trade names Extendryl, AlleRx, Rescon).

Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors.

Methscopolamine is an FDA-approved analog to Hyoscine butylbromide.


  1. ^ Methscopolamine
  2. ^ Gennaro AR. Remington: The Science and Practice of Pharmacy. pp 402-403, 1025. ISBN 0912734043

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