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IUPAC name
  • 207740-46-3
3D model (JSmol)
  • Interactive image
  • 21106340
Molar mass 207.27 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

MADAM-6, or 2,N-dimethyl-4,5-methylenedioxyamphetamine, is a lesser-known recreational drug of the methamphetamine class, similar in structure to MDMA (ecstasy).[1] MADAM-6 was first synthesized by Alexander Shulgin.[2] In Shulgin's book PiHKAL, the minimum dosage is listed as greater than 280 mg, and the duration is unknown.[2] MADAM-6 produces few to no effects and Shulgin describes it as "not active".[2] Very little data exists about the pharmacological properties, metabolism, and toxicity of MADAM-6.

MADAM-6 has been studied for its potential antiparkinsonian effects.[3] However, there are no clinical trials suggesting the drug is effective against Parkinson's disease.

See also


  1. ^ Patt, M; Gündisch, D; Wüllner, U; Blocher, A; Kovar, K. -A; Machulla, H. -J (1999). "N-[11C]methyl-3,4-methylenedioxyamphetamine (Ecstasy) and 2-methyl-N-[11C]methyl-4,5-methylenedioxyamphetamine: Synthesis and biodistribution studies". Journal of Radioanalytical and Nuclear Chemistry. 240 (2): 535. doi:10.1007/BF02349410.
  2. ^ a b c MADAM-6 entry in PiHKAL
  3. ^ US patent US2015025063, Caron; Gainetdinov & Sotnikova, "Antiparkinsonian Action Of Phenylisopropylamines", published 2014-09-30, issued 2015-01-22 
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