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Available structures
PDB Ortholog search: PDBe RCSB
Aliases MYO5B, myosin VB
External IDs MGI: 106598 HomoloGene: 49481 GeneCards: MYO5B
Gene location (Human)
Chromosome 18 (human)
Chr. Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for MYO5B
Genomic location for MYO5B
Band 18q21.1 Start 49,822,813 bp[1]
End 50,195,093 bp[1]
RNA expression pattern
PBB GE MYO5B gnf1h05126 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 18: 49.82 – 50.2 Mb Chr 18: 74.44 – 74.77 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Myosin-Vb is a protein that in humans is encoded by the MYO5B gene.[5][6][7]

Recent evidence suggests that Myosin VB is related to the creation of memories[8] by actin-dependent trafficking of AMPA receptor containing recycling endosomes in dendritic spines.[9]

Mutations of MYO5B cause microvillus inclusion disease[10] and have been associated with bipolar disorder.[11]


MYO5B has been shown to interact with RAB11FIP2.[12]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167306 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025885 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Sep 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi:10.1006/geno.1996.0488. PMID 8884266.
  6. ^ Swiatecka-Urban A, Talebian L, Kanno E, Moreau-Marquis S, Coutermarsh B, Hansen K, Karlson KH, Barnaby R, Cheney RE, Langford GM, Fukuda M, Stanton BA (Aug 2007). "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells". The Journal of Biological Chemistry. 282 (32): 23725–36. doi:10.1074/jbc.M608531200. PMID 17462998.
  7. ^ "Entrez Gene: MYO5B myosin VB".
  8. ^ " Scientists Identify Machinery that Helps Make Memories". Retrieved 2014-03-25.
  9. ^ Wang Z, Edwards JG, Riley N, Provance DW, Karcher R, Li XD, Davison IG, Ikebe M, Mercer JA, Kauer JA, Ehlers MD (Oct 2008). "Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity". Cell. 135 (3): 535–48. doi:10.1016/j.cell.2008.09.057. PMC 2585749. PMID 18984164.
  10. ^ Müller T, Hess MW, Schiefermeier N, Pfaller K, Ebner HL, Heinz-Erian P, Ponstingl H, Partsch J, Röllinghoff B, Köhler H, Berger T, Lenhartz H, Schlenck B, Houwen RJ, Taylor CJ, Zoller H, Lechner S, Goulet O, Utermann G, Ruemmele FM, Huber LA, Janecke AR (Oct 2008). "MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity". Nature Genetics. 40 (10): 1163–5. doi:10.1038/ng.225. PMID 18724368.
  11. ^ Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM (Jun 2008). "Whole-genome association study of bipolar disorder". Molecular Psychiatry. 13 (6): 558–69. doi:10.1038/ PMC 3777816. PMID 18317468.
  12. ^ Hales CM, Vaerman JP, Goldenring JR (Dec 2002). "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". The Journal of Biological Chemistry. 277 (52): 50415–21. doi:10.1074/jbc.M209270200. PMID 12393859.

Further reading

External links

  • GeneTests/NIH/NCBI/UW information Diarrhea with Microvillus Atrophy 2 DIAR2 Microvillus Inclusion Disease MVID gene testing
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