List of investigational hormonal agents

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

This is a list of investigational hormonal agents, or hormonal agents that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Androgenics

Estrogenics

Progestogenics

Glucocorticoidics

Mineralocorticoidics

GnRH/gonadotropins

  • Fezolinetant (ESN-364) – small-molecule NK3 receptor antagonist for hot flashes, polycystic ovary syndrome, and uterine fibroids [31]
  • Linzagolix (KLH-2109, OBE-2109) – small-molecule GnRH receptor antagonist for uterine fibroids and endometriosis [32]
  • Relugolix (RVT-601, TAK-385) – small-molecule GnRH antagonist for prostate cancer, uterine fibroids, and endometriosis [33]

Mixed

See also

References

  1. ^ a b http://www.evestra.com/index-Dateien/Page1242.htm
  2. ^ a b Ahmed G, Elger W, Meece F, Nair HB, Schneider B, Wyrwa R, Nickisch K (October 2017). "A prodrug design for improved oral absorption and reduced hepatic interaction". Bioorg. Med. Chem. 25 (20): 5569–5575. doi:10.1016/j.bmc.2017.08.027. PMID 28886996.
  3. ^ Tong, Youzhi; Chen, Chunyun; Wu, Juan; Yang, Jiangtao; Zhang, Huihui; Wu, Xiaojun; Duan, Yanmei; Gao, Wei; Qian, Weidong; Niu, Xiaoxia; Mi, Lili; Guo, Chuangxing (2014). "Abstract 614: Proxalutamide (GT0918), a potent androgen receptor pathway inhibitor". Cancer Research. 74 (19 Supplement): 614–614. doi:10.1158/1538-7445.AM2014-614. ISSN 0008-5472.
  4. ^ Elger W, Wyrwa R, Ahmed G, Meece F, Nair HB, Santhamma B, Killeen Z, Schneider B, Meister R, Schubert H, Nickisch K (January 2017). "Estradiol prodrugs (EP) for efficient oral estrogen treatment and abolished effects on estrogen modulated liver functions". J. Steroid Biochem. Mol. Biol. 165 (Pt B): 305–311. doi:10.1016/j.jsbmb.2016.07.008. PMID 27449818.
  5. ^ Liu J, Zheng S, Akerstrom VL, Yuan C, Ma Y, Zhong Q, Zhang C, Zhang Q, Guo S, Ma P, Skripnikova EV, Bratton MR, Pannuti A, Miele L, Wiese TE, Wang G (2016). "Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)". J. Med. Chem. 59 (17): 8134–40. doi:10.1021/acs.jmedchem.6b00753. PMID 27529700.
  6. ^ Wang, G; Liu, J; Zheng, S; Miele, L; Wiese, T; Zhong, Q; Guo, S (2017). "Abstract P2-08-11: An orally bioavailable selective estrogen receptor downregulator". Cancer Research. 77 (4 Supplement): P2-08-11–P2-08-11. doi:10.1158/1538-7445.SABCS16-P2-08-11. ISSN 0008-5472.

External links

  • AdisInsight - Springer
  • 2011 Medicines in Development for Women - PhRMA
Retrieved from "https://en.wikipedia.org/w/index.php?title=List_of_investigational_hormonal_agents&oldid=870644139"
This content was retrieved from Wikipedia : http://en.wikipedia.org/wiki/List_of_investigational_hormonal_agents
This page is based on the copyrighted Wikipedia article "List of investigational hormonal agents"; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License (CC-BY-SA). You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA