JWH-149

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JWH-149
JWH-149.png
Legal status
Legal status
Identifiers
CAS Number
  • 548461-82-1 YesY
PubChem CID
  • 45267820
ChemSpider
  • 24627235
UNII
  • AWD731Y25Z
Chemical and physical data
Formula C26H27NO
Molar mass 369.50 g/mol
3D model (JSmol)
  • Interactive image

JWH-149 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-pentyl analog of JWH-148. It is a potent but only moderately selective ligand for the CB2 receptor, with a binding affinity of Ki = 0.73 ± 0.03 nM at this subtype, and more than 6 times selectivity over the CB1 subtype.[1]

See also

References

  1. ^ Huffman, J.; et al. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists". Bioorganic & Medicinal Chemistry. 13 (1): 89–112. doi:10.1016/j.bmc.2004.09.050. PMID 15582455. 


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