Halflife
Number of halflives elapsed 
Fraction remaining 
Percentage remaining 


0  ^{1}⁄_{1}  100  
1  ^{1}⁄_{2}  50  
2  ^{1}⁄_{4}  25  
3  ^{1}⁄_{8}  12  .5 
4  ^{1}⁄_{16}  6  .25 
5  ^{1}⁄_{32}  3  .125 
6  ^{1}⁄_{64}  1  .563 
7  ^{1}⁄_{128}  0  .781 
...  ...  ...  
n  ^{1}/_{2n}  ^{100}/_{2n} 
Halflife (symbol t_{1⁄2}) is the time required for a quantity to reduce to half its initial value. The term is commonly used in nuclear physics to describe how quickly unstable atoms undergo, or how long stable atoms survive, radioactive decay. The term is also used more generally to characterize any type of exponential or nonexponential decay. For example, the medical sciences refer to the biological halflife of drugs and other chemicals in the human body. The converse of halflife is doubling time.
The original term, halflife period, dating to Ernest Rutherford's discovery of the principle in 1907, was shortened to halflife in the early 1950s.^{[1]} Rutherford applied the principle of a radioactive element's halflife to studies of age determination of rocks by measuring the decay period of radium to lead206.
Halflife is constant over the lifetime of an exponentially decaying quantity, and it is a characteristic unit for the exponential decay equation. The accompanying table shows the reduction of a quantity as a function of the number of halflives elapsed.
Contents
Probabilistic nature
A halflife usually describes the decay of discrete entities, such as radioactive atoms. In that case, it does not work to use the definition that states "halflife is the time required for exactly half of the entities to decay". For example, if there is just one radioactive atom, and its halflife is one second, there will not be "half of an atom" left after one second.
Instead, the halflife is defined in terms of probability: "Halflife is the time required for exactly half of the entities to decay on average". In other words, the probability of a radioactive atom decaying within its halflife is 50%.
For example, the image on the right is a simulation of many identical atoms undergoing radioactive decay. Note that after one halflife there are not exactly onehalf of the atoms remaining, only approximately, because of the random variation in the process. Nevertheless, when there are many identical atoms decaying (right boxes), the law of large numbers suggests that it is a very good approximation to say that half of the atoms remain after one halflife.
There are various simple exercises that demonstrate probabilistic decay, for example involving flipping coins or running a statistical computer program.^{[2]}^{[3]}^{[4]}
Formulas for halflife in exponential decay
An exponential decay can be described by any of the following three equivalent formulas:
where
 N_{0} is the initial quantity of the substance that will decay (this quantity may be measured in grams, moles, number of atoms, etc.),
 N(t) is the quantity that still remains and has not yet decayed after a time t,
 t_{1⁄2} is the halflife of the decaying quantity,
 τ is a positive number called the mean lifetime of the decaying quantity,
 λ is a positive number called the decay constant of the decaying quantity.
The three parameters t_{1⁄2}, τ, and λ are all directly related in the following way:
where ln(2) is the natural logarithm of 2 (approximately 0.693).
Click show to see a detailed derivation of the relationship between halflife, decay time, and decay constant. Start with the three equations We want to find relationships among t_{1⁄2}, τ, and λ such that these three equations describe exactly the same exponential decay process. Comparing the equations, we find the following conditions,
Next, we'll take the natural logarithm of each of these quantities.
Using the properties of logarithms, this simplifies to the following:
Since the natural logarithm of e is 1, we get:
Canceling the factor of t and plugging in , the final result is:
By plugging in and manipulating these relationships, we get all of the following equivalent descriptions of exponential decay, in terms of the halflife:
Regardless of how it's written, we can plug into the formula to get
 as expected (this is the definition of "initial quantity")
 as expected (this is the definition of halflife)
 ; i.e., amount approaches zero as t approaches infinity as expected (the longer we wait, the less remains).
Decay by two or more processes
Some quantities decay by two exponentialdecay processes simultaneously. In this case, the actual halflife T_{1⁄2} can be related to the halflives t_{1} and t_{2} that the quantity would have if each of the decay processes acted in isolation:
For three or more processes, the analogous formula is:
For a proof of these formulas, see Exponential decay § Decay by two or more processes.
Examples
There is a halflife describing any exponentialdecay process. For example:
 The current flowing through an RC circuit or RL circuit decays with a halflife of RCln(2) or ln(2)L/R, respectively. For this example, the term half time might be used instead of "half life", but they mean the same thing.
 In a firstorder chemical reaction, the halflife of the reactant is ln(2)/λ, where λ is the reaction rate constant.
 In radioactive decay, the halflife is the length of time after which there is a 50% chance that an atom will have undergone nuclear decay. It varies depending on the atom type and isotope, and is usually determined experimentally. See List of nuclides.
The half life of a species is the time it takes for the concentration of the substance to fall to half of its initial value.
In nonexponential decay
The term "halflife" is almost exclusively used for decay processes that are exponential (such as radioactive decay or the other examples above), or approximately exponential (such as biological halflife discussed below). In a decay process that is not even close to exponential, the halflife will change dramatically while the decay is happening. In this situation it is generally uncommon to talk about halflife in the first place, but sometimes people will describe the decay in terms of its "first halflife", "second halflife", etc., where the first halflife is defined as the time required for decay from the initial value to 50%, the second halflife is from 50% to 25%, and so on.^{[5]}
In biology and pharmacology
A biological halflife or elimination halflife is the time it takes for a substance (drug, radioactive nuclide, or other) to lose onehalf of its pharmacologic, physiologic, or radiological activity. In a medical context, the halflife may also describe the time that it takes for the concentration of a substance in blood plasma to reach onehalf of its steadystate value (the "plasma halflife").
The relationship between the biological and plasma halflives of a substance can be complex, due to factors including accumulation in tissues, active metabolites, and receptor interactions.^{[6]}
While a radioactive isotope decays almost perfectly according to socalled "first order kinetics" where the rate constant is a fixed number, the elimination of a substance from a living organism usually follows more complex chemical kinetics.
For example, the biological halflife of water in a human being is about 9 to 10 days,^{[7]} though this can be altered by behavior and various other conditions. The biological halflife of caesium in human beings is between one and four months.
The concept of a halflife has also been utilized for pesticides in plants,^{[8]} and certain authors maintain that pesticide risk and impact assessment models rely on and are sensitive to information describing dissipation from plants.^{[9]}
See also
References
 ^ John Ayto, 20th Century Words (1989), Cambridge University Press.
 ^ Chivers, Sidney (March 16, 2003). "Re: What happens durring half lifes [sic] when there is only one atom left?". MADSCI.org.
 ^ "RadioactiveDecay Model". Exploratorium.edu. Retrieved 20120425.
 ^ Wallin, John (September 1996). "Assignment #2: Data, Simulations, and Analytic Science in Decay". Astro.GLU.edu. Archived from the original on 20110929.
 ^ Jonathan Crowe, Tony Bradshaw. Chemistry for the Biosciences: The Essential Concepts. p. 568.
 ^ Lin VW; Cardenas DD (2003). Spinal cord medicine. Demos Medical Publishing, LLC. p. 251. ISBN 1888799617.
 ^ Pang, XiaoFeng (2014). Water: Molecular Structure and Properties. New Jersey: World Scientific. p. 451. ISBN 9789814440424.
 ^ Australian Pesticides and Veterinary Medicines Authority (31 March 2015). "Tebufenozide in the product Mimic 700 WP Insecticide, Mimic 240 SC Insecticide". Australian Government. Retrieved 30 April 2018.
 ^ Fantke, Peter; Gillespie, Brenda W.; Juraske, Ronnie; Jolliet, Olivier (11 July 2014). "Estimating HalfLives for Pesticide Dissipation from Plants". Environmental Science & Technology. 48 (15): 8588–8602. Bibcode:2014EnST...48.8588F. doi:10.1021/es500434p. Retrieved 30 April 2018.
External links
Look up halflife in Wiktionary, the free dictionary. 
Wikimedia Commons has media related to Half times. 
 Nucleonica.net, Nuclear Science Portal
 Nucleonica.net, wiki: Decay Engine
 Bucknell.edu, System Dynamics – Time Constants
 Subotex.com, HalfLife elimination of drugs in blood plasma – Simple Charting Tool