HLA-DR9

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
human major histocompatibility complex, class II, DR9
Haplotypes groups DQA*01:DRB1*0901 to

DQA*01:DRB1*0906

Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *0901
Symbol(s) HLA-DRB1
EBI-HLA DRB1*0901
Shared data
Locus chr.6 6p21.31

HLA-DR09 (DR9) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

Serology

DR9 recognition of some DRB1*0901 alleles[1]
DRB1* DR9 Sample
allele % % % size (N)
0901 95 1058

The serological reaction of DR9 is relatively good. The serology of DRB1*0902 to *0906 serotypes is unknown.

Disease associations

DRB1*0901: Early childhood myastenia gravis[2]

Extended linkage

DRB1*0901:DQA1*0301:DQB1*0303 haplotype: Early childhood myastenia gravis[2]

Genetic linkage

DR09 Haplotypes
DRA DRB1
Haplotypes *0101 *0901 *0101
DQA1 DQB1 DRB1
Haplotypes *0301 *0303 *0901
HLA-A HLA-B DRB1
Haplotypes *0000 *0000 *0901

HLA-DR9 is genetically linked to HLA-DR53, and HLA-DQ3 and DQ9 serotypes.

References

  1. ^ derived from IMGT/HLA
  2. ^ a b Shinomiya N, Nomura Y, Segawa M (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan". Clin Immunol. 110 (2): 154–8. doi:10.1016/j.clim.2003.10.004. PMID 15003812. 
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