HLA-DR6

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Illustration of HLA-DR

HLA-DR6 (DR6) is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.

Serology

DR13, DR6 and other serotype recognition of some DRB1*13 and DRB1*14 alleles[1]
DRB1* DR13 DR6 DR14 Sample
allele % % % size (N)
1301 81 14 1 3788
1302 74 17 2 3081
1303 69 10 2 948[2]
1304 87 127
1305 54 12 305[3]
1306 78 9
1307 >50 1
1308 45 55 9
1310 >75 5
DRB1* DR14 DR6 DR13 N
1401 74 14 3 1942
1402 61 13 9 204
1403 72 12 2 37
1404 79 8 80[4]
1405 86 10 58
1406 37 15 22 117
1407 90 10
1408 25 4[5]
1410 >75 4

DR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7.

Disease associations

DR13 and DR14 share a common association to myastenia gravis.[6]

Allele groups

HLA-DRB1*13 and HLA-DRB1*14 encode serotypes of DR6.

References

  1. ^ derived from IMGT/HLA
  2. ^ DR12 - 3%, DR11 - 3% DR5-2%
  3. ^ DR12 - 6%, DR11 - 7% DR5-4%
  4. ^ DR1404 - 3%
  5. ^ DR4 - 25%
  6. ^ Shinomiya N, Nomura Y, Segawa M (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan". Clin Immunol. 110 (2): 154–8. doi:10.1016/j.clim.2003.10.004. PMID 15003812. 
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