HLA-DR5

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Illustration of HLA-DR

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles[1]
DRB1* DR11 DR5 DR12 Sample
allele % % % size (N)
1101 92 5 3474
1102 89 3 430
1103 89 4 397
1104 87 4 2119
1105 75 4
1106 20 73 15
1107 >50 1
1108 >50 2
1109 80 20 5
.
DR12 DR5 DR11 Sample
1201 83 4 2 893 [2]
1202 89 162
1203 >50 3
1206 >50 2

With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy (PGL)[3] and Kaposi sarcoma in AIDS,[4] juvenile rheumatoid arthritis,[5][6] pernicious anemia, Hashimoto's thyroiditis,[7][8] mycosis fungoides,[9] polyglandular deficiency syndrome,[10] systemic sclerosis,[11][12] childhood epilepsy,[13] early-onset alopecia areata,[14] short-ragweed Ra6 allergy,[15] primary antiphospholipid syndrome,[16] and increased longevity in the Dutch[17]

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

References

  1. ^ derived from IMGT/HLA
  2. ^ DR8 - 2%
  3. ^ Raffoux C, David V, Couderc L, Rabian C, Clauvel J, Seligmann M, Colombani J (1987). "HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia". Tissue Antigens. 29 (1): 60–2. doi:10.1111/j.1399-0039.1987.tb01550.x. PMID 3495904. 
  4. ^ Pollack M, Safai B, Myskowski P, Gold J, Pandey J, Dupont B (1983). "Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma". Tissue Antigens. 21 (1): 1–8. doi:10.1111/j.1399-0039.1983.tb00364.x. PMID 6601312. 
  5. ^ Førre O, Dobloug J, Høyeraal H, Thorsby E (1983). "HLA antigens in juvenile arthritis. Genetic basis for the different subtypes". Arthritis Rheum. 26 (1): 35–8. doi:10.1002/art.1780260106. PMID 6401993. 
  6. ^ Suciu-Foca N, Jacobs J, Godfrey M, Woodward K, Khan R, Reed E, Rohowsky C (1980). "HLA-DR5 in juvenile rheumatoid arthritis confined to few joints". Lancet. 2 (8184): 40. doi:10.1016/S0140-6736(80)92920-7. PMID 6104257. 
  7. ^ Farid N, Sampson L, Moens H, Barnard J (1981). "The association of goitrous autoimmune thyroiditis with HLA-DR5". Tissue Antigens. 17 (3): 265–8. doi:10.1111/j.1399-0039.1981.tb00700.x. PMID 6947505. 
  8. ^ Schleusener H, Schernthaner G, Mayr W, Kotulla P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel K (1983). "HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter". J Clin Endocrinol Metab. 56 (4): 781–5. doi:10.1210/jcem-56-4-781. PMID 6131902. 
  9. ^ Safai B, Myskowski P, Dupont B, Pollack M (1983). "Association of HLA-DR5 with mycosis fungoides". J Invest Dermatol. 80 (5): 395–7. doi:10.1111/1523-1747.ep12553615. PMID 6601679. 
  10. ^ Shapiro M, Zamir R, Weiss E, Radnay J, Shenkman L (1987). "The polyglandular deficiency syndrome: a new variant in Persian Jews". J Endocrinol Invest. 10 (1): 1–7. doi:10.1007/bf03347139. PMID 3496374. 
  11. ^ Pereira S, Black C, Welsh K, Ansell B, Jayson M, Maddison P, Rowell N (1987). "Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families". J Rheumatol. 14 (4): 760–5. PMID 3499513. 
  12. ^ Luderschmidt C, Scholz S, Mehlhaff E, König G, Albert E (1987). "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles". Arch Dermatol. 123 (9): 1188–91. doi:10.1001/archderm.123.9.1188. PMID 3498440. 
  13. ^ Minev M, Martinova F, Belopitova L (1987). "On the association of the HLA system with epilepsy in children". Epilepsia. 28 (1): 74–6. doi:10.1111/j.1528-1157.1987.tb03626.x. PMID 3098558. 
  14. ^ Orecchia G, Belvedere M, Martinetti M, Capelli E, Rabbiosi G (1987). "Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata". Dermatologica. 175 (1): 10–4. doi:10.1159/000248775. PMID 3497062. 
  15. ^ Marsh D, Freidhoff L, Ehrlich-Kautzky E, Bias W, Roebber M (1987). "Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans". Immunogenetics. 26 (4–5): 230–6. doi:10.1007/BF00346517. PMID 3498688. 
  16. ^ Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum. 38 (9): 1340–1. doi:10.1002/art.1780380925. PMID 7575732. 
  17. ^ Lagaay A, D'Amaro J, Ligthart G, Schreuder G, van Rood J, Hijmans W (1991). "Longevity and heredity in humans. Association with the human leucocyte antigen phenotype". Ann N Y Acad Sci. 621: 78–89. doi:10.1111/j.1749-6632.1991.tb16970.x. PMID 1859103. 
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