HLA-DR18

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR18
Haplotypes groups DRA*01:DRB1*0302 DRA*01:DRB5*0303
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *0302 *0303
Symbol(s) HLA-DRB1
EBI-HLA DRB5*0302
EBI-HLA DRB1*0303
Shared data
Locus chr.6 6p21.31

HLA-DR18 (DR18) is a HLA-DR serotype that recognizes the DRB1*0302 and *0303 gene products. Compared to DR17 which is found at high frequency in Western Europe, DR18 is found more in SE Europe and Central Asia.

Serology

DR18 recognition of some DRB1*03 alleles[1]
DRB1* DR18 DR3 DR17 Sample
allele  %  %  % size (N)
0302 66 24 3 317
0303 60 40 5

DR18 recognizes the DRB1*0302 and *0303, the thoroughness of recognition is fair, but better than DR3.

Disease associations

DR18 seropositivity is associated with rheumatoid polyarthritis[2]

DRB1*0302 is positively associated with juvenile diabetes,[3] nuclear helicase Mi-2 autoantibodies in inflammatory inclusion body myositis.[4]

Genetic Linkage

DR18 Haplotypes
Serotypes DRA DRB1 DRB3
DR18(3)-DR52 *0101 *0302 *0101
DQA1 DQB1 DRB1
D18(3)-DQ2(2.5) *0501 *0201 *0302
HLA-A HLA -B DRB1
A33-B58-DR18(3) *3301 *5801 *0302

HLA-DR18 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.

References

  1. ^ derived from IMGT/HLA
  2. ^ Dieye A, Diallo S, Diatta M, Thiam A, Ndiaye R, Bao O, Sarthou J (1997). "[Identification of HLA-DR alleles for susceptibility to rheumatoid polyarthritis in Senegal]". Dakar Med. 42 (2): 111–3. PMID 9827131. 
  3. ^ Shawkatova I, Michalkova D, Barak L, Fazekasova H, Kuba D, Buc M (2006). "HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients". Bratislavské lekárske listy. 107 (3): 76–9. PMID 16796128. 
  4. ^ Sivakumar K, Semino-Mora C, Dalakas MC (1997). "An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families". Brain. 120 ( Pt 4) (4): 653–661. doi:10.1093/brain/120.4.653. PMID 9153127. 
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