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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR16
Haplotypes groups DRA*01:DRB1*1601 DRA*01:DRB1*1602
Structure (See HLA-DR)
alpha *0101
Symbol(s) HLA-DRA
beta 1 *1601 *1602 *1604
Symbol(s) HLA-DRB1
Shared data
Locus chr.6 6p21.31

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.


DR16, DR2 and other serotype recognition of some DRB1*16 alleles[1]
DRB1* DR16 DR2 DR15 Sample
allele % % % size (N)
1601 41 29 19 703
1602 47 30 16 239
1604 >50 1

Disease associations

DR16 is associated with Chaga's cardiomyopathy,[2] rheumatic heart disease,[3] coronary artery ectasia,[4] and chronic discoid lupus erythematosus.[5]

DRB1*1601 is associated with tuberculosis risk[6]

DRB1*1602: Juvenile rheumatoid arthritis,[7] rheumatic heart disease,[3] Takayasu arteritis,[8] systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody,[9][10] melioidosis (Burkholderia pseudomallei infection)[11]

Extended linkage

DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk [6]

    • *1602:DQA1*0102:DQB1*0502 haplotype: graves disease,[12][13] cervical cancer (human papilloma virus infection),[14] scleroderma[10]
    • *1602:DQA1*05:DQB1*0301 haplotype: rheumatic heart disease,[3] systemic sclerosis[15]

Genetic Linkage

DR16 Haplotypes
Serotypes DRA DRB1 DRB5
DR16(2)-DR51 *0101 *1601 *0101
*0101 *1602 *0101
*0101 *1604 *0101
DR16(2)-DQ5 (5.2, 1) *0102 *0502 *1601
A2-B51(5)-DR16(2) *0201 *5101 *1601

HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.


  1. ^ derived from IMGT/HLA
  2. ^ Cruz-Robles D, Reyes P, Monteón-Padilla V, Ortiz-Muñiz A, Vargas-Alarcón G (2004). "MHC class I and class II genes in Mexican patients with Chagas disease". Hum Immunol. 65 (1): 60–5. doi:10.1016/j.humimm.2003.10.008. PMID 14700597.
  3. ^ a b c Hernández-Pacheco G, Aguilar-García J, Flores-Domínguez C, Rodríguez-Pérez J, Pérez-Hernández N, Alvarez-Leon E, Reyes P, Vargas-Alarcón G (2003). "MHC class II alleles in Mexican patients with rheumatic heart disease". Int J Cardiol. 92 (1): 49–54. doi:10.1016/S0167-5273(03)00040-8. PMID 14602216.
  4. ^ Akdemir R, Ozhan H, Gunduz H, Erbilen E, Yazici M, Duran S, Orkunoglu F, Albayrak S, Imirzalioglu N, Uyan C (2004). "HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia". Acta Cardiol. 59 (5): 499–502. doi:10.2143/AC.59.5.2005222. PMID 15529553.
  5. ^ López-Tello A, Rodríguez-Carreón AA, Jurado F, et al. (2007). "Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients". Clin. Exp. Dermatol. 32 (4): 435–8. doi:10.1111/j.1365-2230.2007.02391.x. PMID 17376212.
  6. ^ a b Dubaniewicz A, Moszkowska G, Szczerkowska Z (2005). "Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report". Tuberculosis (Edinb). 85 (4): 259–67. doi:10.1016/j.tube.2004.12.003. PMID 15958261.
  7. ^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
  8. ^ Salazar M, Varela A, Ramirez L, Uribe O, Vasquez G, Egea E, Yunis E, Iglesias-Gamarra A (2000). "Association of HLA-DRB1*1602 and DRB1*1001 with in Colombian mestizos as markers of Amerindian ancestry". Int J Cardiol. 75 Suppl 1: S113–6. PMID 10980348.
  9. ^ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
  10. ^ a b Tan F, Stivers D, Arnett F, Chakraborty R, Howard R, Reveille J (1999). "HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)". Tissue Antigens. 53 (1): 74–80. doi:10.1034/j.1399-0039.1999.530108.x. PMID 10082433.
  11. ^ Dharakul T, Vejbaesya S, Chaowagul W, Luangtrakool P, Stephens H, Songsivilai S (1998). "HLA-DR and -DQ associations with melioidosis". Hum Immunol. 59 (9): 580–6. doi:10.1016/S0198-8859(98)00052-4. PMID 9757914.
  12. ^ Wongsurawat T, Nakkuntod J, Charoenwongse P, Snabboon T, Sridama V, Hirankarn N (2006). "The association between HLA class II haplotype with Graves' disease in Thai population". Tissue Antigens. 67 (1): 79–83. doi:10.1111/j.1399-0039.2005.00498.x. PMID 16451208.
  13. ^ Park M, Park Y, Song E, Park H, Kim T, Park D, Park K, Cho B (2005). "Association of HLA-DR and -DQ genes with Graves disease in Koreans". Hum Immunol. 66 (6): 741–7. doi:10.1016/j.humimm.2005.03.001. PMID 15993720.
  14. ^ Cervantes J, Lema C, Valentina Hurtado L, Andrade R, Hurtado Gomez L, Torrico L, Zegarra L, Quiroga G, Asturizaga D, Dulon A, Prada R, Panoso W, Yashiki S, Fujiyoshi T, Sonoda S (2003). "HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women". Hum Immunol. 64 (9): 890–5. doi:10.1016/S0198-8859(03)00163-0. PMID 12941545.
  15. ^ Arnett F, Howard R, Tan F, Moulds J, Bias W, Durban E, Cameron H, Paxton G, Hodge T, Weathers P, Reveille J (1996). "Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype". Arthritis Rheum. 39 (8): 1362–70. doi:10.1002/art.1780390814. PMID 8702445.
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