HLA-DR13

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR13
Haplotypes groups DQA*01:DRB1*1301 to DQA*01:DRB1*1309 DQA*01:DRB1*1310 DQA*01:DRB1*1312 ....
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA
EBI-HLA DRA*0101
Identifiers
beta 1 *1301 to *1308 *1310
Symbol(s) HLA-DRB1
EBI-HLA DRB1*1301
EBI-HLA DRB1*1302
EBI-HLA DRB1*1304
EBI-HLA DRB1*1306
EBI-HLA DRB1*1307
EBI-HLA DRB1*1310
Shared data
Locus chr.6 6p21.31

HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.

Alleles

DR13, DR6 and other serotype recognition of some DRB1*13 alleles[1]
DRB1* DR13 DR6 DR14 Sample
allele % % % size (N)
1301 81 14 1 3788
1302 74 17 2 3081
1303 69 10 2 948[2]
1304 87 127
1305 54 12 305[3]
1306 78 9
1307 >50 1
1308 45 55 9
1310 >75 5

Serotypes are unknown the following alleles: DRB1*1309, *1315 to *1379 DRB1*13 allele group

  • 81 Alleles: 74 proteins
  • DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314
  • DR6 (weak DR13) Serotype: *1308
  • DR13&Other serotypes: *1303, *1305, *1311,
  • Serotype unknown: *1309, *1315 to *1374

Disease associations

DRB1*1302 is linked to early childhood myastenia gravis.[4] Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.

Extended linkage

DRB1*1302:DQA1*0102:DQB1*0604 Early childhood myastenia gravis[4]

Genetic Linkage

DR13 Haplotypes
DRA DRB1 DRB3
DR13(6)-DR52 *0101 *1301 *0101
*0101 *1301 *0201
*0101 *1302 *0301
DQA1 DQB1 DRB1
DR13(6)-DQ6(6.3, 1) *0103 *0603 *1301
DR13(6)-DQ6(6.4, 1) *0102 *0604 *1302
DR13(6)-DQ6(6.5, 1) *0102 *0605 *1302
DR13(6)-DQ6(6.9, 1) *0102 *0609 *1302
HLA-A HLA-B DRB1
A2-Cw5-B44(16)-DR13 *02 *4402 *1301

HLA-DR13 is genetically linked to DR52[5] and HLA-DQ6 (HLA-DQ1) serotypes.

References

  1. ^ derived from IMGT/HLA
  2. ^ DR12 - 3%, DR11 - 3% DR5-2%
  3. ^ DR12 - 6%, DR11 - 7% DR5-4%
  4. ^ a b Shinomiya N, Nomura Y, Segawa M (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan". Clin Immunol. 110 (2): 154–8. doi:10.1016/j.clim.2003.10.004. PMID 15003812.
  5. ^ Song EY, Park H, Roh EY, Park MH (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol. 65 (3): 270–6. doi:10.1016/j.humimm.2003.12.005. PMID 15041167.
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