GRN-529

From Wikipedia, the free encyclopedia
GRN-529
GRN-529.svg
Identifiers
CAS Number
  • 1253291-12-1
PubChem CID
  • 59548652
IUPHAR/BPS
  • 6428
ChemSpider
  • 27471591
Chemical and physical data
Formula C22H15F2N3O2
Molar mass 391.11 g/mol
3D model (JSmol)
  • Interactive image

GRN-529 is a drug that was developed by Wyeth as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5).[1]

A study conducted by Pfizer found that GRN-529 reduced repetitive behaviors without sedation and partially increased sociability in mouse models of autism. [2]

Another study conducted by Pfizer found a therapeutically relevant effect in animal models of depression. It is theorized to work by reducing glutamate receptor hyperactivity.[3]

See also

References

  1. ^ US Patent Application No. 20100273772 "96 dpi image of original application USPTO 2010273772" (PDF). Retrieved 26 May 2012. 
  2. ^ Silverman, J. L.; Smith, D. G.; Rizzo, S. J. S.; Karras, M. N.; Turner, S. M.; Tolu, S. S.; Bryce, D. K.; Smith, D. L.; et al. (2012). "Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism". Science Translational Medicine. 4 (131): 131ra51. doi:10.1126/scitranslmed.3003501. PMC 4904784Freely accessible. PMID 22539775. 
  3. ^ Hughes, ZA; Neal, SJ; Smith, DL; Sukoff Rizzo, SJ; Pulicicchio, CM; Lotarski, S; Lu, S; Dwyer, JM; Brennan, J; Olsen, M.; Bender, C.N.; Kouranova, E.; Andree, T.H.; Harrison, J.E.; Whiteside, G.T.; Springer, D.; O'Neil, S.V.; Leonard, S.K.; Schechter, L.E.; Dunlop, J.; Rosenzweig-Lipson, S.; Ring, R.H. (2012). "Negative allosteric modulation of metabolic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression". Neuropharmacology. 66: 202. doi:10.1016/j.neuropharm.2012.04.007. PMID 22551786. 

External links

  • GRN-529 - AdisInsight



Retrieved from "https://en.wikipedia.org/w/index.php?title=GRN-529&oldid=828901912"
This content was retrieved from Wikipedia : http://en.wikipedia.org/wiki/GRN-529
This page is based on the copyrighted Wikipedia article "GRN-529"; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License (CC-BY-SA). You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA