Fluticasone furoate

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Fluticasone furoate
Fluticasone furoate.svg
Clinical data
AHFS/Drugs.com International Drug Names
License data
  • EU EMAby INN
Pregnancy
category
  • C for Intranasal
Routes of
administration
Intranasal
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 0.51% (Intranasal)
Protein binding 91%
Metabolism Intranasal
Hepatic (CYP3A4-mediated)
Elimination half-life 15 hours
Excretion Renal
Identifiers
CAS Number
  • 80474-14-2
PubChem CID
  • 9854489
DrugBank
  • DB00588
ChemSpider
  • 8030195
UNII
  • JS86977WNV
ChEBI
  • CHEBI:74899
ChEMBL
  • CHEMBL1676
ECHA InfoCard 100.158.130
Chemical and physical data
Formula C27H29F3O6S
Molar mass 538.576 g/mol
3D model (JSmol)
  • Interactive image

Fluticasone furoate is a synthetic corticosteroid derived from fluticasone, marketed by GlaxoSmithKline as Veramyst and Flonase Sensimist (US), Allermist (Japan, アラミスト) and Avamys (Australia, Canada, EU, South Africa, South America, Mexico, Israel, Italy and South Korea) for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.[1]

The combination drug fluticasone furoate/vilanterol, marketed as Breo Ellipta (US, Canada) and Relvar Ellipta (UK), is approved for use in the United States by the Food and Drug Administration for long-term maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema.[2] As of 2015, it is also approved for the treatment of asthma. [3]

See also

References

  1. ^ Bruni FM, De Luca G, Venturoli V, Boner AL (2009). "Intranasal corticosteroids and adrenal suppression". Neuroimmunomodulation. 16 (5): 353–62. doi:10.1159/000216193. PMID 19571596.
  2. ^ "FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease". Food and Drug Administration. May 10, 2013.
  3. ^ "BREO® ELLIPTA® 100/25 (fluticasone furoate 100 mcg and vilanterol 25 mcg inhalation powder)" (PDF).


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