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Clinical data
Routes of
Legal status
Legal status
Pharmacokinetic data
Biological half-life 106 hours
CAS Number
  • 2647-50-9 YesY
PubChem CID
  • 12947024
  • 10441497
  • GKX573279U
Chemical and physical data
Formula C15H10BrFN2O
Molar mass 333.16 g/mol
3D model (JSmol)
  • Interactive image

Flubromazepam is a benzodiazepine derivative which was first synthesized in 1960,[1] but was never marketed and did not receive any further attention or study until late 2012 when it appeared on the grey market as a novel designer drug.[2][3][4][5][6][7]

It is a structural analog of phenazepam in which the chlorine atom has been replaced by a fluorine atom.

An alternate isomer, 5-(2-bromophenyl)-7-fluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one or "iso-flubromazepam",[8] may have been sold under the same name.[2]

Alternate isomer

Legal status

United Kingdom

In the UK, flubromazepam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other designer benzodiazepine drugs.[9]

United States

Clonazolam, Flubromazepam, Flubromazolam have now all been placed into Schedule I under Virginia State Law.[10]

See also


  1. ^ US 3136815, "Amino substituted benzophenone oximes and derivatives thereof" 
  2. ^ a b Bjoern Moosmann; Laura M. Huppertz; Melanie Hutter; Armin Buchwald; Sascha Ferlaino; Volker Auwärter (November 2013). "Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics". Journal of Mass Spectrometry. 48 (11): 1150–1159. doi:10.1002/jms.3279. PMID 24259203. 
  3. ^ B. Moosmann; M. Hutter; L. M. Huppertz; V. Auwärter. "Characterization of the designer benzodiazepines pyrazolam and flubromazepam and study on their detectability in human serum and urine samples" (PDF). Institute of Forensic Medicine, Forensic Toxicology, University Medical Center Freiburg, Freiburg, Germany. 
  4. ^ Lauren C. O'Connor; Hazel J. Torrance; Denise A. McKeown (March 2016). "ELISA Detection of Phenazepam, Etizolam, Pyrazolam, Flubromazepam, Diclazepam and Delorazepam in Blood Using Immunalysis® Benzodiazepine Kit". Journal of Analytical Toxicology. 40 (2): 159–161. doi:10.1093/jat/bkv122. PMID 26518230. 
  5. ^ "Flubromazepam". New Synthetic Drugs Database. 
  6. ^ Madeleine Pettersson Bergstrand; Anders Helander; Therese Hansson; Olof Beck (2016). "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Testing and Analysis. doi:10.1002/dta.2003. PMID 27366870. 
  7. ^ Høiseth, Gudrun; Tuv, Silja Skogstad; Karinen, Ritva (2016). "Blood concentrations of new designer benzodiazepines in forensic cases". Forensic Science International. 268: 35–38. doi:10.1016/j.forsciint.2016.09.006. PMID 27685473. 
  8. ^ Baumeister D, Tojo LM, Tracy DK. Legal highs: staying on top of the flood of novel psychoactive substances. Therapeutic Advances in Psychopharmacology. 2015;5(2):97-132. doi:10.1177/2045125314559539.
  9. ^ "The Misuse of Drugs Act 1971 (Amendment) Order 2017". 
  10. ^ http://law.lis.virginia.gov/admincode/title18/agency110/chapter20/section322/.  Missing or empty |title= (help)

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