EMR3

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ADGRE3
Identifiers
Aliases ADGRE3, EMR3, adhesion G protein-coupled receptor E3
External IDs OMIM: 606101 HomoloGene: 50009 GeneCards: ADGRE3
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ADGRE3
Genomic location for ADGRE3
Band 19p13.12 Start 14,619,117 bp[1]
End 14,690,027 bp[1]
RNA expression pattern
PBB GE EMR3 210724 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289158
NM_001289159
NM_032571
NM_152939

n/a

RefSeq (protein)

NP_001276087
NP_001276088
NP_115960

n/a

Location (UCSC) Chr 19: 14.62 – 14.69 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene.[3][4] EMR3 is a member of the adhesion GPCR family.[5][6] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[7]

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[8] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[9] Mice, next to Emr2, lack the Emr3 gene.[10]

Function

The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[11]

Ligands

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131355 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry. 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179. 
  4. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687Freely accessible. PMID 25713288. 
  5. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  6. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. 
  7. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182Freely accessible. PMID 22333914. 
  8. ^ Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J (Feb 2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". Journal of Leukocyte Biology. 81 (2): 440–8. doi:10.1189/jlb.0406276. PMID 17108056. 
  9. ^ a b Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry. 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179. 
  10. ^ Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J (Dec 2006). "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal. 20 (14): 2582–4. doi:10.1096/fj.06-6500fje. PMID 17068111. 
  11. ^ "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3". 

External links

  • GPCR consortium
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