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Nucleosome=DNA + histones: Crystal structure[1]). Histones H2A, H2B, H3 and H4 are proper colored, DNA is gray.
Nucleosome: DNA + histone configuration


Deoxyribonucleoprotein (DNP) is the complex of DNA and protein[2] in which DNA is usually found upon cell disruption and isolation.[3][4]

The most widespread deoxyribonucleoproteins are nucleosomes, in which the component is nuclear DNA. The proteins combined with DNA are histones and protamines; the resulting nucleoproteins are located in chromosomes. Thus, the entire chromosome, i.e. chromatin in eukaryotes consists of such nucleoproteins.[5][6]


Many viruses are little more than an organized collection of deoxyribonucleoproteins.

Recombination intermediates

Homologous recombination is a process for repairing DNA that appears to be nearly universal. A central intermediate step in this process is the interaction of multiple copies of a recombinase protein with single-stranded DNA to form a DNP filament. Recombinases employed in this process are produced by archaea (RadA recombinase)[7], by bacteria (RecA recombinase)[8] and by eukaryotes from yeast to humans (Rad51 and Dmc1 recombinases).[9]

See also


  1. ^ RasTop (Molecular Visualization Software).
  2. ^ Deoxyribonucleoproteins at the US National Library of Medicine Medical Subject Headings (MeSH)
  3. ^
  4. ^ "deoxyribonucleoprotein (DNP, Dnp)". 
  5. ^ Graeme K. Hunter G. K. (2000): Vital Forces. The discovery of the molecular basis of life. Academic Press, London 2000, ISBN 0-12-361811-8.
  6. ^ Nelson D. L., Michael M. Cox M. M. (2013): Lehninger Principles of Biochemistry. W. H. Freeman, ISBN 978-1-4641-0962-1.
  7. ^ Seitz EM, Brockman JP, Sandler SJ, Clark AJ, Kowalczykowski SC (1998). "RadA protein is an archaeal RecA protein homolog that catalyzes DNA strand exchange". Genes Dev. 12 (9): 1248–53. PMC 316774Freely accessible. PMID 9573041. 
  8. ^ Cox MM, Goodman MF, Kreuzer KN, Sherratt DJ, Sandler SJ, Marians KJ (2000). "The importance of repairing stalled replication forks". Nature. 404 (6773): 37–41. doi:10.1038/35003501. PMID 10716434. 
  9. ^ Crickard JB, Kaniecki K, Kwon Y, Sung P, Greene EC (2018). "Spontaneous self-segregation of Rad51 and Dmc1 DNA recombinases within mixed recombinase filaments". J. Biol. Chem. doi:10.1074/jbc.RA117.001143. PMID 29382724. 

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