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D-161 structure.png
PubChem CID
  • 11545250
  • 9720029
Chemical and physical data
Formula C25H27NO2
Molar mass 373.486 g/mol
3D model (JSmol)
  • Interactive image

D-161[1] is a chemical known in research circles as a triple reuptake inhibitor. Although this compound has lent support to the inclusion of dopamine in the monoamine hypothesis of depression, D-161 has not been tested in clinical trials.


  1. ^ Dutta, A.; Ghosh, B.; Biswas, S.; Reith, M. (2008). "D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action". European Journal of Pharmacology. 589 (1–3): 73–79. doi:10.1016/j.ejphar.2008.05.008. PMID 18561912. 
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