Clortermine

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Clortermine
Clortermine.svg
Clinical data
Synonyms 2-chloro-α,α-dimethylphenethylamine;
2-chloro-α-methylamphetamine;
2-chlorophentermine
Pregnancy
category
  •  ?
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
Identifiers
CAS Number
  • 10389-73-8 ☒N
PubChem CID
  • 25223
DrugBank
  • DB01527 ☑Y
ChemSpider
  • 23558 ☑Y
UNII
  • 4FA88HM3IX
KEGG
  • D03566 ☑Y
ChEMBL
  • ChEMBL1697833 ☒N
CompTox Dashboard (EPA)
  • DTXSID0022850
Chemical and physical data
Formula C10H14ClN
Molar mass 183.68 g/mol g·mol−1
3D model (JSmol)
  • Interactive image
 ☒N☑Y (what is this?)   (verify)

Clortermine (Voranil) was developed by Ciba in the 1960s[1] and is an anorectic drug of the amphetamine class.[2] It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,[3] and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent.[citation needed]

See also

References

  1. ^ US patent 3415937, "The Suppression of Appetite with 1-(o-Chlorophenyl)-2-Methyl-2-Propylamine" 
  2. ^ Triggle, D. J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall / CRC. ISBN 0-412-46630-9.
  3. ^ Sannerud, C. A.; Brady, J. V.; Griffiths, R. R. (1989). "Self-Injection in Baboons of Amphetamines and Related Designer Drugs". NIDA Research Monograph. 94: 30–42. PMID 2514366.


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