Carteolol

From Wikipedia, the free encyclopedia
Carteolol
Carteolol skeletal.svg
Clinical data
Trade names Ocupress
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a601078
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration
Eye drops
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 85%
Metabolism Hepatic, active with 8-hydrocarteolol
Elimination half-life 6–8 hours
Excretion Renal (50-70%)
Identifiers
CAS Number
  • 51781-06-7
PubChem CID
  • 2583
IUPHAR/BPS
  • 7142
DrugBank
  • DB00521 YesY
ChemSpider
  • 2485 YesY
UNII
  • 8NF31401XG
KEGG
  • D07624 YesY
ChEBI
  • CHEBI:3437 YesY
ChEMBL
  • CHEMBL839 YesY
Chemical and physical data
Formula C16H24N2O3
Molar mass 292.373 g/mol
3D model (JSmol)
  • Interactive image
Chirality Racemic mixture
  (verify)

Carteolol (trade names Cartrol, Ocupress, Teoptic, Arteolol, Arteoptic, Calte, Cartéabak, Carteol, Cartéol, Cartrol, Elebloc, Endak, Glauteolol, Mikelan, Poenglaucol, Singlauc) is a non-selective beta blocker used to treat glaucoma.

It has been found to act as a serotonin 5-HT1A and 5-HT1B receptor antagonist in addition to being a beta blocker.[1]

References

  1. ^ Langlois M, Brémont B, Rousselle D, Gaudy F (1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". Eur. J. Pharmacol. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601. 

External links

  • El-Kamel A, Al-Dosari H, Al-Jenoobi F (2006). "Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride". Drug Deliv. 13 (1): 55–9. doi:10.1080/10717540500309073. PMID 16401594. 
  • Kuwahara K, Oizumi N, Fujisawa S, Tanito M, Ohira A (2005). "Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro". Cornea. 24 (2): 213–20. doi:10.1097/01.ico.0000141232.41343.9d. PMID 15725891. 
  • Trinquand C, Romanet J, Nordmann J, Allaire C (2003). "[Efficacy and safety of long-acting carteolol 1% once daily. A double-masked, randomized study]". J Fr Ophtalmol. 26 (2): 131–6. PMID 12660585. 



Retrieved from "https://en.wikipedia.org/w/index.php?title=Carteolol&oldid=830126200"
This content was retrieved from Wikipedia : http://en.wikipedia.org/wiki/Carteolol
This page is based on the copyrighted Wikipedia article "Carteolol"; it is used under the Creative Commons Attribution-ShareAlike 3.0 Unported License (CC-BY-SA). You may redistribute it, verbatim or modified, providing that you comply with the terms of the CC-BY-SA