CNTRL

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CNTRL
Identifiers
Aliases CNTRL, CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDs MGI: 1889576 HomoloGene: 38260 GeneCards: CNTRL
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for CNTRL
Genomic location for CNTRL
Band 9q33.2 Start 121,074,863 bp[1]
End 121,177,610 bp[1]
RNA expression pattern
PBB GE CEP110 205642 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007018
NM_001330762

NM_001290635
NM_012018
NM_030000

RefSeq (protein)

NP_001317691
NP_008949

NP_001277564
NP_036148

Location (UCSC) Chr 9: 121.07 – 121.18 Mb Chr 9: 35.11 – 35.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.[5][6]

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119397 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057110 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)". Blood. 95 (5): 1788–96. PMID 10688839. 
  6. ^ a b "Entrez Gene: CEP110 centrosomal protein 110kDa". 

External links

Further reading



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