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Clinical data
Routes of
ATC code
Pharmacokinetic data
Excretion Renal
CAS Number
  • 528-92-7 ☑Y
PubChem CID
  • 10715
  • 10264 ☑Y
  • V18J24E25E
  • D03975 ☑Y
  • CHEMBL509282 ☑Y
ECHA InfoCard 100.007.677
Chemical and physical data
Formula C9H16N2O2
Molar mass 184.236 g/mol
3D model (JSmol)
  • Interactive image
Chirality Racemic mixture

Apronal (brand name Sedormid), or apronalide, also known as allylisopropylacetylurea or allylisopropylacetylcarbamide, is a hypnotic/sedative drug of the ureide (acylurea) group synthesized in 1926[1] by Hoffmann-La Roche that is no longer used except in Japan (See Japanese article). Though it is not a barbiturate, apronalide is similar in structure to the barbiturates (being an open-chain carbamide instead of having a heterocyclic ring).[2] In accordance, it is similar in action to the barbiturates, although considerably milder in comparison (formerly used as a daytime sedative at doses of 1 to 2 grams every 3 to 4 hours).[2] Upon the finding that it caused patients to develop thrombocytopenic purpura, apronalide was withdrawn from clinical use.[3]

See also


  1. ^ DE Patent 459903 - Verfahren zur Darstellung von Ureiden der Dialkylessigsaeuren
  2. ^ a b Roche Review ... Hoffman-La Roche, and Roche-organon. 1938. p. 164.
  3. ^ R. L. Vollum; D. G. Jamison; C. S. Cummins (20 May 2014). Fairbrother's Textbook of Bacteriology. Elsevier Science. pp. 152–. ISBN 978-1-4831-4178-7.

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