Antazoline

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Antazoline
Antazoline.svg
Clinical data
Trade names Vasocon-a
AHFS/Drugs.com Micromedex Detailed Consumer Information
Routes of
administration
Topical (nasal, eye drops)
ATC code
Identifiers
CAS Number
  • 91-75-8 ☑Y
PubChem CID
  • 2200
IUPHAR/BPS
  • 7116
DrugBank
  • DB08799 ☑Y
ChemSpider
  • 2115 ☑Y
UNII
  • DHA8014SS1
KEGG
  • D07458 ☑Y
ChEBI
  • CHEBI:84115 ☒N
ChEMBL
  • CHEMBL1305 ☑Y
ECHA InfoCard 100.001.904
Chemical and physical data
Formula C17H19N3
Molar mass 265.353 g/mol
3D model (JSmol)
  • Interactive image
 ☒N☑Y (what is this?)  (verify)

Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.[1] To treat allergic conjunctivitis, antazoline can be combined in a solution with tetryzoline.[2] The drug is a Histamine H1 receptor antagonist:[3] selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.

References

  1. ^ Abelson MB, Allansmith MR, Friedlaender MH (1980). "Effects of topically applied ocular decongestant and antihistamine". Am J Ophthalmol. 90 (2): 254–7. doi:10.1016/s0002-9394(14)74864-0. PMID 7425039.
  2. ^ Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis". Cochrane Database Syst Rev. 6: CD009566. doi:10.1002/14651858.CD009566.pub2. PMID 26028608.
  3. ^ Noguchi, Seiji; Inukai, Toshiya; Kuno, Takayoshi; Tanaka, Chikako (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f. PMID 1353628.


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