Androsterone glucuronide

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Androsterone glucuronide
Androsterone glucuronide.svg
Names
IUPAC name
(2S,3S,4S,5R,6R)-6-[[(3R,5S,8R,9S,10S,13S,14S)-10,13-Dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
Other names
ADT-G; 5α-Androstan-3α-ol-17-one 3-glucuronide; 17-Oxo-5α-androstan-3α-yl β-D-glucopyranosiduronic acid
Identifiers
  • 1852-43-3
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:28832
ChemSpider
  • 102793
KEGG
  • C11135
PubChem CID
  • 114833
Properties
C25H38O8
Molar mass 466.571 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Androsterone glucuronide (ADT-G) is a major circulating and urinary metabolite of testosterone and dihydrotestosterone (DHT).[1] It accounts for 93% of total androgen glucuronides in women.[1] ADT-G is formed from androsterone by UDP-glucuronosyltransferases, with the major enzymes being UGT2B15 and UGT2B17.[1] It is a marker of acne in women while androstanediol glucuronide is a marker of hirsutism (excess hair growth) in women.[2]

See also

References

  1. ^ a b c http://www.hmdb.ca/metabolites/HMDB02829
  2. ^ Jerome F. Strauss, III; Robert L. Barbieri (13 September 2013). Yen and Jaffe's Reproductive Endocrinology. Elsevier Health Sciences. pp. 837–. ISBN 978-1-4557-2758-2.

External links

  • Metabocard for Androsterone Glucuronide (HMDB02829) – Human Metabolome Database



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