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Cobamamide 3D sticks.png
Clinical data
AHFS/ International Drug Names
Routes of
ATC code
Legal status
Legal status
CAS Number
  • 13870-90-1 ☑Y
PubChem CID
  • 5459907
  • 16736117 ☑Y
  • D00042 ☑Y
  • CHEBI:18408 ☒N
CompTox Dashboard (EPA)
  • DTXSID1046009
ECHA InfoCard 100.034.192
Chemical and physical data
Formula C72H100CoN18O17P
Molar mass 1579.58 g/mol g·mol−1
 ☒N☑Y (what is this?)   (verify)

Adenosylcobalamin (AdoCbl), also known as coenzyme B12, cobamamide, and dibencozide, is, along with methylcobalamin (MeCbl), one of the biologically active forms of vitamin B12.[1]

Adenosylcobalamin participates as a cofactor in radical-mediated 1,2-carbon skeleton rearrangements. These processes require the formation of the deoxyadenosyl radical through homolytic dissociation of the carbon-cobalt bond. This bond is exceptionally weak, with an bond dissociation energy of 31 kcal/mol, which is further lowered in the chemical environment of an enzyme active site.[2] An enzyme that uses adenosylcobalamin as a cofactor is methylmalonyl-CoA mutase (MCM).


  1. ^ Marsh EN, Meléndez GD (November 2012). "Adenosylcobalamin enzymes: theory and experiment begin to converge". Biochimica et Biophysica Acta. 1824 (11): 1154–64. doi:10.1016/j.bbapap.2012.03.012. PMC 3580769. PMID 22516318.
  2. ^ Kräutler B, Arigoni D, Golding BT (1998). Vitamin B12 and B12-proteins : lectures presented at the 4th European Symposium on Vitamin B12 and B12-Proteins. Weinheim: Wiley-VCH. ISBN 9783527612192. OCLC 212131311.

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