APICA (drug)

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APICA (mGluR antagonist).svg
Clinical data
ATC code
  • none
  • 3881975 ☑Y
  • CHEMBL277961 ☑Y
Chemical and physical data
Formula C10H12NO5P
Molar mass 257.179 g/mol
3D model (JSmol)
  • Interactive image

1-Amino-5-phosphonoindan-1-carboxylic acid (APICA) is a drug that is used in neuroscience research. It is a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and has been useful in the study of this receptor subfamily.[1][2][3][4][5]


  1. ^ Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 1997 May 6;7(9):1195-1198. doi:10.1016/S0960-894X(97)00177-7
  2. ^ Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. Journal of Organic Chemistry. 1999 Jan 8;64(1):120-125. PMID 11674092
  3. ^ Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. Journal of Pharmacology and Experimental Therapeutics. 2002 Jan;300(1):162-71. doi:10.1124/jpet.300.1.162 PMID 11752112
  4. ^ Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. Journal of Neuroscience. 2002 Oct 15;22(20):9134-41. PMID 12388621
  5. ^ Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G. Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. Journal of Neuroscience Research. 2006 Aug 1;84(2):268-77. PMID 16752416
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