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CAS Number
  • 131556-11-1 N
PubChem CID
  • 131397
  • 116144 YesY
Chemical and physical data
Formula C15H21N
Molar mass 215.3339 g/mol
3D model (JSmol)
  • Interactive image
 NYesY (what is this?)  (verify)

8a-Phenyldecahydroquinoline (8A-PDHQ) is a high affinity NMDA antagonist developed by a team at Parke Davis in the 1950s.[1] It is a structural analog of phencyclidine with slightly lower binding affinity than the parent compound. (-)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801.[2][3]


  1. ^ US Patent 3035059
  2. ^ Chen C; Kozikowski AP; Wood PL; Reynolds IJ; Ball RG; Pang YP (1992). "Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency". Journal of Medicinal Chemistry. 35 (9): 1634–8. doi:10.1021/jm00087a020. PMID 1315871. 
  3. ^ Elhallaoui M; Laguerre M; Carpy A; Ouazzani FC (2002). "Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode". J Mol Model. 8 (2): 65–72. doi:10.1007/s00894-001-0067-4. PMID 12032600. 

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