4-Hydroxyestrone

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4-Hydroxyestrone
4-Hydroxyestrone.svg
Names
IUPAC name
(8R,9S,13S,14S)-3,4-Dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
Other names
4-OHE1; Estra-1,3,5(10)-triene-3,4-diol-17-one; 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one
Identifiers
  • 3131-23-5
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:87602
ChEMBL
  • ChEMBL1743300
ChemSpider
  • 8146843
PubChem CID
  • 9971251
UNII
  • 3MN57C55S2
Properties
C18H22O3
Molar mass 286.37 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

4-Hydroxyestrone (4-OHE1), also known as estra-1,3,5(10)-triene-3,4-diol-17-one, is an endogenous, naturally occurring catechol estrogen and a minor metabolite of estrone and estradiol.[1][2][3] It is estrogenic, similarly to many other hydroxylated estrogen metabolites such as 2-hydroxyestradiol, 16α-hydroxyestrone, estriol (16α-hydroxyestradiol), and 4-hydroxyestradiol but unlike 2-hydroxyestrone.[1][4]

See also

References

  1. ^ a b Michael Oettel; Ekkehard Schillinger (6 December 2012). Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. pp. 224, 232, 244–245, 249. ISBN 978-3-642-58616-3. 
  2. ^ David Rakel (2012). Integrative Medicine. Elsevier Health Sciences. pp. 338–. ISBN 1-4377-1793-4. 
  3. ^ H.J. Buchsbaum (6 December 2012). The Menopause. Springer Science & Business Media. pp. 64–65. ISBN 978-1-4612-5525-3. 
  4. ^ Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK (2000). "Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women". J. Soc. Gynecol. Investig. 7 (3): 175–83. PMID 10865186. 

External links

  • Metabocard for 4-Hydroxyestrone - Human Metabolome Database


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